Sink your teeth into meaty drama and intrigue with House, FOX's new take on mystery, where the villain is a medical malady and the hero is an irreverent, controversial doctor who trusts no one, least of all his patients. On the compelling series premiere episode, Dr. Gregory House, a brilliant diagnostician but devoid of bedside manner, and his elite team of young medical experts rush to save the life of a kindergarten teacher (guest star Robin Tunney) who started speaking gibberish and passed out in front of her class. What looks like a possible brain tumor does not respond to treatment and provides many more questions than answers for House and his team as they engage in a risky trial-and-error approach to her case. When the young teacher refuses any additional variations of treatment and her life starts slipping away, House must act against his code of conduct and make a personal visit to his patient to convince her to trust him one last time.

When a teen-aged lacrosse player is stricken with an unidentifiable brain disease, House and the team hustle to give his parents answers. Chase breaks the bad news, the kid has MS, but the boy's whacked-out hallucinations disprove the diagnosis and send the team back to square one. As the boy's health deteriorates, House's side-bet on the paternity of the patient infuriates the kid's parents, but may just pay off in spades.

When a college student collapses after a bout of raucous sex with his girlfriend, Dr. House and his team scramble to figure out why. He’s got too many symptoms to add up to just one disease and soon his immune system is so perilously compromised a simple cold could kill him. As his condition deteriorates quickly, House needs to think - and get more Vicodin. But when Wilson nags House about his nasty pill habit it proves extremely useful to House, just not in the way Wilson intended.

House exasperates Cuddy when he suggests that two sick babies in one hospital add up to an epidemic. Even more frightening is when it turns out he may be right. As more babies are quarantined and the maternity ward is shut down, Cuddy powerscrubs the hospital and House spars with Cameron and the team over his plan to sacrifice one baby for the good of the rest.

When a nun comes into the clinic with swollen arms, a rash and bleeding in her palms, Dr. House’s diagnosis is a bad allergy, not stigmata. However, when he gives her a shot of medication, she has a heart attack, and whether he gave her the correct amount of medicine comes into question. As the nun’s case unfolds, the team has to deal with questions regarding their own calling, faith and whether or not they can trust the direction in which their mentor is leading them.

When all signs point to a schizophrenic with deadly DVT lying about her alcohol intake, Dr. House is the lone voice of reason. Under the scrutiny of her hyper-vigilant young son, House takes her off all medication and secretly sends Foreman and Chase to search her apartment for clues. Wading through her altered reality to get to the truth and save her life, House discovers that it isn't mom who's keeping the secrets and reality isn't always what it seems.