Hoss and Little Joe are mistaken for bloodthirsty hired killers in a small Texas town dominated by two feuding families.
The Cartwrights come to the aid of a Chinese-American stable hand accused of murder.
The Cartwrights try to disprove the validity of a Spanish land grant to stop De La Cuesta family from seizing part of the Ponderosa and all of the Carson Valley settlers' lands.
Jeb Drummond is a murderous sheep herder that has Adam taken hostage to try and force Ben to sign over a large section of Ponderosa land to him.
When a brutal U.S. Marshal arrests one of the Ponderosa's workers for murder to transport him to Los Angeles for trial, and a doubtful Hoss and Adam come along in the stagecoach.
Inspector Leduque comes from New Orleans to Virginia City to take Ben Cartwright back for a 20 year murder. Ben declares publicly that he is withdrawing from the Governor's race.