On the series premiere, eight drug addicted celebrities check themselves into rehab under the care of Dr. Drew Pinsky and begin their difficult battle for sobriety. As each celebrity (Brigitte Nielsen, Joanie "Chyna Doll" Laurer, Jeff Conaway, Daniel Baldwin, Seth "Shifty" Binzer, Mary Carey, Jaimee Foxworth & Jessica Sierra) is introduced, their painful backstory and struggle with drugs is profiled. Dr. Drew begins to analyze and assess his patients' struggles through a series of one-on-one meetings, but his attention is pulled away by a drunken, doped up Jeff Conaway who lapses into a seizure and ends up being rushed to the hospital.

Viewing Jeff Conaway's extraordinary and harsh detox, the rehabbers get to see what rehab is really about. The rehabbers watch Jeff's struggle in horror and wonder, could this happen to them? Overwhelmed, Jessica spirals into an emotional tailspin, but she finds some solace when Brigitte comforts her about her broken relationship with her drug addicted, prostitute mother. While Jeff continues to battle his withdrawal symptoms in the hospital, emotions flare for the rest of the group when it is revealed that Jeff brought drugs into the rehab.

Jeff finally returns from the hospital, but while he continues to detox, Drew lectures Jeff's co-dependant girlfriend about her own bad habits will kill Jeff. Meanwhile, another celebrity joins the group, former Ultimate Fighting Champion, Rico Rodriguez. Rico doesn't exactly hit it off with the women in the group and he gets an earful from Jessica during his first group meeting. Later, Dr. Drew works with Mary Carey on how to leave behind her porn star lifestyle, but Daniel tries to lure her back into her sex-charged ways when he entices her into a forbidden flirtation.

Our rehabbers deal with their painful and abusive pasts, as many of them are affected by physical, sexual or mental trauma from a very early age. Dr. Drew explores their various issues, having the group work as a whole to overcome their problems.

Everyone reels after finding out about the inappropriate text messaging between Daniel and Mary, so Dr. Drew is charged with pulling the group back together.

The process is coming close to the end, so Dr. Drew must start preparing the group how to live a sober life in the real world.