Panama and Barbados open Group D of World Cup qualifying knowing that all three points are crucial for qualification.
Mexico are the favorite to win Group A and should be set for all three points against Antigua & Barbuda, who gave up four goals in their first match.
Antigua & Barbuda were blown away by Mexico last time out, but get the chance to bounce back against Anguilla at home in North Sound.
Cayman Islands look to bounce back from a 6-0 loss on the second matchday, taking on Grenada who sit at the bottom of Group C
Saint Kitts & Nevis take on Curacao with both teams needing all three points to have any hope of qualifying from Group B
St. Vincent and the Grenadines host British Virgin Islands with both teams yet to score a goal, conceding a combined 32 goals in the first two matches.