The premiere episode finds Nanny Deb, a 22-year veteran of the nanny wars, answering the cry of help from the Rock family. Parents Matt and Karen have lost control of their household to their 4-year-old son Dylan and 2-year-old daughter Natalie. Dylan has a penchant for foul language and temper tantrums, while Natalie is well on her way to following in her brother’s footsteps. At their wits’ end, Matt and Karen have turned to Nanny 911 to tame their little terrors and get order their Southern California home back.

Meet the McCrays: Dad, Craig, is a New York City cop, feels guilty about being away from his kids and indulges their every whim to the point of going behind Mom's back; while Tracey is exhausted by their constant demands and violent behavior. Nine year old CJ is introduced as the ringleader who constantly stirs up trouble and terrorizes the younger boys. Six-year-old Mikey climbs all over the furniture, Jojo, three, is babied along with the two-year-old twins, Jack and Francis, who can barely talk and constantly hit their mother and each other. What a rabble, but can the kids be cured?

In another episode of unruly mayhem, Nanny Deb finds herself visiting the McRoberts Family. With support and guidance from Nanny Lillian at Nanny Central and one of her family plans being ‘brothers for life’, this is sure to be another happy ending...Or is it?

The Priore family might just have met their match in Nanny Stella. 10-year-old daughter and a set of 8-year-old quadruplets are driving parents Joe and Nina mad. The children are strong-willed and the eldest quadruplet daughter and son are in a serious power struggle. Siblings Lynne, John and Nicole try and stay out of the way, but at times get caught in the crossfire. This is sure to be a must-see episode of sibling-rivalry.

Nanny Stella might just have her hands full with the Lorimor Family. Her family plan includes ‘no hitting or biting’ and teamwork on behalf of the parents but will congratulating the children when they behave and disciplining them when they don’t actually work?

Nanny Yvonne has her work cut out with the Johnston family, consisting of seven girls, all under the age of 8 and two very exhausted parents. Assigned to the case by Head Nanny Lillian, she has packed her bag of tricks and is heading to New York to work her Mary Poppins-like magic on this unruly bunch.