Dr Choi and Dr Charles have difficult decisions to make as a dying man tries to preserve his life with a controversial scientific method; Dr Marcel and April clash over how to handle a mysterious patient; Will questions Natalie's capabilities.
Maggie gets unsettling news about a new friend and breaks protocol to support him; one of the doctors from the Med family is rushed into emergency surgery after a violent assault; a social media influencer lets his users vote on medical advice.
April receives unfortunate news that makes her question her future with Ethan; Dr Charles and Maggie see tough times on the horizon; Natalie's memory from the accident starts to return.
Dr Halstead's world is thrown into turmoil when a former patient resurfaces; April has a secret she considers confessing to Ethan; Dr Charles tries to maintain his focus during a difficult time.
Dr Charles and Dr Halstead sink their teeth into a bloodthirsty case; Dr Marcel and Maggie throw a traditional crayfish boil for the staff; a new relationship blossoms while another is left on rocky ground.