Much to Bell's dismay, Nic and Conrad decide to admit a homeless Jane Doe, whom they suspect was dumped off by another hospital during Chastain's big Charity Ball.
Devon's doubts about his relationship reach a peak as his friends and family gather for his big wedding day; as Chastain's medical device company continues to succeed, Julian makes a discovery that leaves her uneasy about her involvement in it.
After a long wait, Conrad and Nic prepare for their wedding day; flashbacks to the early days of the COVID-19 crisis shine a light on the heroism of the doctors and the toll the virus took on everyone at Chastain Memorial.
In the aftermath of a deadly attack on the White House, Elizabeth tries to keep a major nuclear disarmament deal from falling apart.