Bailey and a team of surgeons must remove a young girl's inoperable tumour; as the new head of trauma, Owen Hunt challenges the surgical abilities of the residents and the attending doctor's methods.
A woman, using her professional skills as a call girl, becomes the team's target as she goes after high-powered executives.
Jane and the team narrowly escape a fiery end when a building explodes while they are investigating a death threat. Meanwhile, sparks fly between Lisbon and billionaire Walter Mashburn when they meet again during a case.
Susan gets some surprising news while on a romantic weekend with Ian; Lynette continues to support the family as Tom chases his dreams.
When an Arctic explorer is killed during a polar expedition, the mysterious circumstances of his death take Castle and Beckett from the penthouses of Park Avenue to the halls of the CIA.