Dr. Murphy becomes obsessed with performing an autopsy on a Jane Doe, which challenges his relationships at the hospital; a male college student has a mysterious split personality disorder.

A patient with a mysterious and undiagnosed illness that has baffled other doctors for years forces Dr. Shaun Murphy and the team to take some big risks. Meanwhile, Dr. Claire Brown and Dr. Neil Melendez continue to cautiously navigate their feelings for each other as colleagues and friends.

Dr. Claire Browne and Dr. Shaun Murphy treat a patient with a rare form of dwarfism. Meanwhile, Dr. Morgan Reznick, Dr. Audrey Lim and Dr. Alex Park treat a young man who had both arms torn off in a previous farming accident; and Shaun reacts to an emotional situation.

In the first episode of the two-part season finale, the city of San Jose is rocked by an earthquake that puts the staff of St. Bonaventure Hospital on high alert as they race to assess the damage and account for the safety of their colleagues and friends. Meanwhile, Dr. Neil Melendez and Dr. Aaron Glassman are attending a charity event when their lives are threatened by the earthquake.

In the second episode of the two-part finale, our doctors work against time and their own personal safety to save the lives of those around them on the season finale of "The Good Doctor."

Lea and Shaun's new relationship will become tested. Park gets ready to move back to Phoenix. Morgan puts herself and several members of the staff in danger. Claire continues to work through her grief from the death of Melendez.

Shaun has a hard time balancing his fears and concerns about potentially jeopardizing Lea's health and wanting to be with the woman he loves. Claire looks for a way to grieve Melendez's death. Park and Mia discuss their future together.

With several candidates vying for residency at St. Bonaventure, Lim tasks Shaun, Claire and Alex with mentoring the top first-year resident contenders; Shaun inadvertently insults Lea while discussing the pros and cons of a controversial surgery.

Morgan and Shaun's pregnant patient with twins has pain, forcing the doctors to grapple with a decision no one wants to make; Shaun asks Lea to move back in despite her reservations.

Dr. Murphy questions his decision to give the new residents autonomy when an intern's misdiagnosis has dire consequences; a patient has a ruptured cyst affecting key functions of her brain; Dr. Morgan Reznick and Park bond over failed relationships.

Dr. Audrey Lim struggles to cope with the residual emotional trauma of COVID-19; Dr. Claire Browne suggests a radical treatment to help a war veteran who has PTSD; Dr. Shaun Murphy declares he doesn't want to teach the new residents any more.