As the 4400 return, the government tries to understand the phenomenon and analyze the potential threat; an empathetic social worker and a hardened community corrections officer are among the civil servants tapped to deal with the uncanny refugees.
As the 4400 become even more disenchanted with their accommodations, new rules have everyone on edge. Andre (TL Thompson) and LaDonna (Khaila Johnson) help Claudette (Jaye Ladymore) push her new-found ability to new limits. Keisha (Ireon Roach) and Jharrell (Joseph David-Jones) explore a way to ease the tension for a small group of the returned and Shanice (Brittany Adebumola) gets an unexpected visitor. Meanwhile, Rev (Derrick A. King) begins to believe he may be part of a higher calling, but what will that mean for the rest of the 4400?
LaDonna (Khaila Johnson) signs up for fifteen more minutes of fame but quickly realizes she doesn�t have the clout she once had, so she turns to an unlikely source to help further her agenda, meanwhile Jharrell (Joseph David-Jones) picks an inopportune time to speak his truth, and it may cost him dearly. Andre (TL Thompson) is eager to get back to medicine while everyone is eager to feel a bit of normalcy again. Shanice (Brittany Adebumola) takes a step towards repairing her relationship with her daughter and Hayden (AMARR) and Mildred (Autumn Best) enjoy an impromptu celebration.
Finally there is some good news for a few of the 4400. Andre (TL Thompson) looks to study some of his new friends but mistakes from his past begin to affect him in present day. Rev (Derrick A. King) finds some information about his son.
Keisha (Ireon Roach) hears the truth about the day she lost her sister, moving her to take a chance. Shanice (Brittany Adebumola) and Andre (TL Thompson) enjoy a day out, meanwhile, Hayden (AMARR) and Mariah (guest star Sophia Echendu) grow closer.
Jharrel (Joseph David Jones) and Keisha (Ireon Roach) must earn the trust of the 4400 if they truly want to help keep them safe. Hayden (AMARR) convinces LaDonna (Khailah Johnson) and Andre (TL Thompson) to visit Ypsi Med and Rev (Derrick A. King) continues to grow his flock.
Joseph David Jones
Jharrel Mateo
Ireon Roach
Keisha
Brittany Adebumola
Shanice
T L Thompson
Dr. Andre
Derrick A. King
Rev. Johnson