Winston Story

Cristina tells Alex and Bailey about Izzie's condition; Mark is doing a face transplant on a patient and Owen and Alex are the donor gathering team; Bailey sends Callie after Derek to bring him back and Callie ends up staying in his vortex of self-pity.

Derek prepares to perform his first surgery since his breakdown; Owen has a PTSD episode which injures Cristina and puts their relationship in jeopardy.

Izzie returns to work while the Seattle Grace residents fear possible layoffs; Bailey and Alex's difficult case is further complicated by her schizophrenic son.

Meredith's old friend, Sadie comes to Seattle Grace making Cristina jealous; Richard looks to woo the new surgeon; the interns start cutting each other to practice their suturing techniques.

A group of college students are rushed to Seattle Grace following a serious car crash on their way to the graduation ceremonies; Izzie continues feeling similar symptoms.

Derek searches for the best way to propose to Meredith; Callie tries to convince Mark not to blow his chance at real love with Lexie, despite his fear of Derek finding out; Izzie learns she has anemia.