When an attempted robbery goes wrong, three career criminals (Brody, Malkovich & Culkin) make a run for it, hiding out in an abandoned industrial building as they wait to make their next move. Unfortunately they’re not alone in the warehouse; the group are terrified to discover the bloodied presence of De Niro, an attack dog who’s been left behind by an underground fight circuit, abandoned by his owner, gangster Blue (Antonio Banderas). Trying to keep their distance from this new threat, and with the law closing in, the group fast become their own worst enemies, as they explore the love, fear and conditioning and all the wrong turns that have put them in the dog house, fighting for their lives.