Mare Winningham

George begins to overstay his welcome; Meredith learns a secret about her father; Bailey gets back into a surgery room; Alex gets a lesson in bedside manners.

Recent events strain Burke and Cristina's relationship; Meredith's half sister enters the hospital; Mark and Derek must work together when two close-knit brothers seek medical help.

Das Gerangel um den Chefarztposten wird noch heftiger, als ein neuer Kandidat auf der Bildfläche erscheint. Die Spannungen zwischen Izzie und George entladen sich in einem riesigen Donnerwetter und Callie muss ein Geheimnis lüften. Unterdessen operiert Derek eine Patientin, die ihm ans Herz gewachsen ist, und Alex kümmert sich weiterhin um seinen namenlosen Fall.

Izzie faces her past and finds comfort in George; Alex has an attachment to Jane Doe; Meredith and Derek question their status; Cristina resolves to fight for her relationship with Burke.

Addison takes a temporary leave from Seattle Grace and visits old friends in Los Angeles; Cristina reluctantly plans her wedding with help from Burke's mother (Diahann Carroll) and her own; Derek must perform surgery on Jane Doe.