In the heart of Cajun country, young mother Brenda DuPont is found murdered in her home in May 1988. The initial investigation sputters and turns cold, but Brenda's older sister Linda vows to solve Brenda's murder, no matter how long it takes.

In a city of eight million, landlord Bruce Blackwood disappears without a trace in March 2006. Though there is no body, the NYPD is sure this is a homicide and they, along with Bruce's brother Ed, spend the next nine years searching for answers and a killer.

The body of Lori Nesson is found in a ditch in 1974, but the search for her killer finally begins when the cause of death is changed to homicide 40 years later.

A fire in January 2007 claims the life of WWII vet Bennie Angelo; a closer look at the crime scene reveals Bennie was dead before the fire, bumping an arson case up to homicide.

When 30-year-old mother Lisa Gaudenzi fails to report for duty in Virginia, the Army lists her as AWOL; her family immediately suspects foul play, so they embark on a 13-year quest for answers before an eyewitness blows the case wide open.

Frank McAlister disappears from the quiet town of Redding, California; he is a teen with a recent cash windfall who leaves only a blood-stained car behind; 25 years will pass before someone makes a stunning on-air confession.