Novice screenwriter Marty (Farrell) has come down with a bad case of writers block and is struggling to find inspiration for his new script Seven Psychopaths. All he needs is a little focus and inspiration. Billy (Rockwell) is Marty's best friend, an unemployed actor and part-time dog thief, who wants to help Marty by any means necessary. Hans (Walken) is Billy's partner in crime. Charlie (Harrelson) is the psychopathic gangster whose beloved dog Billy and Hans have just stolen. Charlie is unpredictable, extremely violent and wouldn't think twice about killing anyone and anything associated with the theft. Marty is going to get all the focus and inspiration he needs, just as long as he lives to tell the tale.