An old friend's heart problems reveal a bigger issue than anticipated; Devon treats a suicidal woman who he thinks might be a good candidate for deep brain stimulation; Billie and Trevor have an emotional reunion.
MacGyver and Riley must find a way to drive a tanker filled with liquid oxygen through a region occupied by rebels and deliver it to a children's hospital; Riley helps MacGyver decide whether or not to allow his father back into his life.
A warlock who triggered the Salem witch trials escapes purgatory; Abbie tries to regain trust in Frank Irving; Henry searches for his identity.
At Josh’s first day on the job, tempers rise over the cappuccino machine. Dad tells Josh he wants to propose to Mae. Arnold’s psychiatrist insists Josh and Arnold can only go on a ‘safe date’. Complications ensue.
Nick asks Dylan for help finding the killer when a neighbor is murdered by a vampire; Claire tries to end her arrangement with Christian; Andie decides to stop taking her medicine.