Cristina won't allow herself to get excited when she is nominated for a Harper Avery award, and Alex thinks about making a change. Callie and Derek work with a machine that recognises emotions.
The doctors are exposed to flu-infected patients; Derek prepares to give a speech; a new doctor gives Alex a glimpse into an alternative medical practice.
Meredith learns Amelia's true feelings about Seattle; Bailey deals with the consequences of her actions; Callie receives terrible news; news of a firing causes panic among the residents.
Cristina considers her future at the hospital; Amelia and Derek collaborate on a tough surgery involving conjoined twins; Jo takes on too many cases at once; Stephanie stumbles on the truth about Bailey's case.
Jackson must deliver bad news to the doctors; Derek's sister visits; Richard surprises Catherine in Boston; Bailey makes a risky decision about her research.