The chaos of a hospital emergency room and the lives of its devoted doctors and staff, a Chicago building collapses, and everyone in the ER must overcome personal dramas to save lives.
Third year medical student Abby Lockhart begins her ER rotation; John Carter tries to help a kid with muscular dystrophy; Luka and Carol treat a young boy whose mother is injecting him with saline to get surgical procedures done.
Dr Weaver goes on the warpath after she discovers several problems in the ER; Dr Greene re-evaluates his priorities in the wake of his father's death.
Corday spends a stressful Thanksgiving Day with Greene's father and daughter; Kovac rescues Hathaway who goes into labour at the station, and returns her to County General where she gives birth to twins.
Dr Kovac fears he may have made a mistake when he transports a girl to the hospital before the paramedics arrive.