Changing roles and colleagues prove a test for the doctors as Rhodes and Choi face new environments and problems.
April is injured while treating a difficult patient, as Dr Manning struggles with her past. Dr Rhodes, meanwhile, faces a challenge.
A husband has a strange request after the death of his wife. Dr Charles deals with a patient who wants to amputate his own arm.
Dr Choi and Dr Charles are tested with an erratic patient presenting unusual symptoms; Dr Manning is suspicious about the cause of a boy's broken arm.
Dr Halstead treats a former high school classmate. Doctors Manning and Charles try to treat a young patient who refuses to take medication.