Don fears a bioterrorist strike when a number of random people fall ill and die unexpectedly, and Charlie must locate patient zero to prevent further fatalities.
Grissom and his team uncover unusual evidence in the murder of a man who, because of a genetic disorder, looked like a werewolf.
Carrie discovers that her latest love interest is bisexual. Meanwhile, Samantha asserts her dominance at work, and Miranda acts out while feeling suffocated by Steve.
Rory studies up on Logan's father (Gregg Henry) before beginning work for him as an intern; Lorelei sees a side of Logan that makes her worry about Rory's involvement with the Huntzberger family.