Dr. Marcel and Dr. Manning lay everything on the line to assist a sick woman; Dr. Halstead faces an uphill battle in getting participants involved in his clinical trial; Dr. Choi clashes with a patient who demands absolute perfection of himself.
Dr. Halstead finds continued success in his trial; Dr. Charles' daughter, Anna, receives life-changing news; Noah finds himself in a situation not even April can fix.
Choi teams up with an unexpected person to treat a famous tennis player who is afraid his career might be over; Goodwin's new protocols cause a stir.
Halstead runs into trouble when one of his trial patients falls ill; his own stress and symptoms have Choi struggling to get through the day.
Marcel deals with a patient who ends up having more in common with him than he thinks; Halstead and Choi clash over a pregnant patient with an irregular heartbeat.