Jack Merrill

Mr. Big tells Carrie (Sarah Jessica Parker) he will never marry again; Samantha (Kim Cattrall) is harshly dumped.

Cristina treats a former Seattle Grace scrub nurse and is forever changed. Izzie's past comes back to haunt her and makes a case difficult.

A sexually transmitted disease infects several members of hospital staff. Izzie and Cristina worry about a patient whose wife and daughter are at odds over his care. A bombshell is dropped just as Meredith and Derek grow closer.

Caleb wants Kirsten to get rid of Julie, Sandy and Kirsten tire of Ryan, Ryan and Luke agree to work together against Oliver, and Marissa learns the truth about Oliver.

Don and his team look into the murder of a young woman in an up-and-coming actor's Hollywood Hills mansion.

After Emily's biggest take-down goes awry she relies on help from an unlikely source. Victoria tries to secure her independence and Nolan heads to Florida to find out more about Patrick's past.