The doctors compete for a new position; Meredith finds it hard to stay focused; Maggie becomes the keeper of a large secret; Amelia and Owen work on their relationship; Jo and Alex's honeymoon does not go according to plan.
Two Seattle firefighters head to Grey Sloan following the rescue of two boys from a house fire. The doctors continue work on their surgical innovation contest projects, and Tom Koracick is brought in to consult.
The new doctors continue to shake things up in the hospital; Meredith forms a connection with a patient; Jackson finds it difficult to find the meaning behind his recent experiences; Jo forges an unexpected alliance.
Meredith treats a patient who specialises in matchmaking. A seemingly drunk patient pushes Richard's buttons and gives him a medical mystery to solve. Maggie tries to reach Teddy after the burden of her secret becomes overwhelming.
Maggie and Clive's relationship starts to progress after she invites him over for a game night to meet Amelia and Meredith; Jo and Meredith meet with the owner of the patent to the polymer they need for their project.