When a family arrives at Seattle Grace Hospital after a serious car accident, Alex learns that their injuries are only the beginning of their problems.
Meredith fights to keep her emotions in check when a secret about her mother is revealed; Alex and Izzie grow close.
Cristina goes straight back to work after her discharge; a young woman's traditionalist, religious father won't allow her to have a life-saving operation.
Meredith and George are at odds at work; Bailey treats Addison; Alex is jealous when Izzie pays more attention to Denny.
Izzie copes with the loss of Denny and her decision to leave the internship program; Meredith faces decisions about her future after her liaison with Derek.