Alex treats a patient whose religious beliefs place her life in jeopardy. Meredith wants to know more about Derek, and Izzie ponders contacting her estranged mother.
Brennan and Booth race the clock to tie up loose ends before the defendant in Booth's first FBI case is executed for the crime.
Frasier attempts to work his psychoanalyses on a self-confessed lazy criminal, Phil, who has stolen his briefcase and his car. To make matters worse, Phil is masquerading as the real Frasier Crane.
While investigating a homicide with Catherine (Marg Helgenberger), a shocked Gil (William Petersen) discovers that a prime suspect has been missing for decades; Warrick and Sara (Gary Dourdan, Jorja Fox) try to explain what seems like a physical impossibility.
Addison and Charlotte fight to save the lives of a woman in a coma and her unborn child; members of the Oceanside staff clash with Meg; when a patient is suspected of murdering his wife, Violet seeks Kevin's advice.