A recent attendee at a popular motivational speaker's conference in Seattle is murdered. The BAU looks at the speaker as the main suspect, but they have to refocus their investigation when the speaker himself goes missing.
The team is involved in an international incident as they investigate the murder of of an American petty officer, whose body was found aboard a British ship.
House and Wilson disagree on the outcome of a boxing match they bet on; the team suspect House of having another drug problem.
Jack and Cole team up to protect New York City from the catastrophic threat. Meanwhile, CTU is further buckled by a hostage situation and Prady's presence.