In search of a cure for the Mark of Cain, Castiel comes up with an idea that Sam does not support; as Rowena plots against Crowley, Castiel tries to make things right with Claire.
When Castiel finds Jimmy's daughter in a group home, she persuades him to break her out; Crowley is faced with a big challenge.
Castiel asks Sam and Dean to help Claire find her mother, but when they learn what took the woman, they suspect a happy ending is impossible.
Jody Mills looks to Claire Novak for help when Sam and Dean go missing. A number of women come together and prepare to head off on the most important hunt of their lives.
Claire Novak is attacked while Sam and Dean try to save her from a terrible fate which would change her life forever.