A young woman clings to life after a brutal attack, leaving the surgical staff optimistic. Meredith puts her career on the line to save a newborn in the hospital nursery.
A train crash brings several seriously injured patients to the hospital, providing a distraction for Meredith as she awaits Derek's final decision.
Cristina, Izzie, and Meredith are fascinated by the case of male patient; a sheltered young patient inspires Alex to better express his feelings for Izzie.
A series of deaths at the hospital brings out the superstitious side of the doctors and makes Izzie nervous about Denny's surgery; Derek and Addison discuss living arrangements; Richard treats an old friend.
Cristina is awarded the first solo surgery among the residents, but she is forced to give it up and choose her replacement; Lexie is impressed when Mark performs a cutting-edge procedure; Callie doesn't know if Sadie is friendly or flirtatious.