As Bull prepares for fatherhood, his work at TAC suffers without his top attorney Benny, who quit in reaction to Bull's romantic reconnection to Isabella; the team must mount a defence for a young bartender on trial for involuntary manslaughter.
Max and Sharpe wake up to a new, more personal dynamic; Iggy calls upon an old contact to help with an explosive situation; Bloom begins a tricky dynamic with her new Emergency Department residents; Reynolds finds himself in an awkward position.
Max works to find a new normal, three months after the accident and the birth of his daughter; Kapoor grapples with the stigma of aging; Iggy has a successful day that inspires a life-changing idea; Reynolds deals with an unreliable new intern.
With the hospital on lockdown after the Rikers patients escape, Sharpe and Max find themselves in a situation that could cost them their lives; Bloom must put aside her pain to help a patient; Iggy is forced to face his marriage's issues.
It's National HIV Testing Day and Max offers free care to all HIV-positive patients who come to New Amsterdam; Bloom and Reynolds butt heads over their opposing bedside manners; Iggy eagerly awaits the return of a friend; Sharpe makes a discovery.