Alex treats a patient whose religious beliefs place her life in jeopardy. Meredith wants to know more about Derek, and Izzie ponders contacting her estranged mother.
Terrorists attack the United Nations delegation in Geneva as Elizabeth prepares to leave the State Department and announce her run for president.
Elizabeth deals with the consequences of a news article that claims she had an affair with President Dalton during her days at the CIA. Plus, Jay and Mike B. adjust to their roles as campaign staffers.
When Russia threatens to invade Bulgaria, Elizabeth must seek NATO's support. The alliance's existence is threatened however, when France refuse to cooperate.
When dealing with the Russian government, the president's administration comes across hostility. Dmitri is interrogated about being a spy.
