McGee goes to a women's prison to interview a suspect in a murder case. When a prison guard is murdered nearby, the prisoners take control of the wing, fearing they will be blamed for the guard's death. McGee convinces them to let him investigate the guard's murder. Now he must find the murderer amongst all the other criminals before the warden handles the situation in his own way.
After reuniting with her mother, Veronica must find Neptune High's kidnapped mascot in time for an important basketball game. Her suspicions about the Kane family reappear.
While Stevie goes into shock over Kitty and Abe's divorce, Dewey finds he likes the taste of baby food.
The whole family gets involved when Ruthie goes on her first official date.
When Annie learns that Matt and Sarah will not be home for Thanksgiving, she begins to act strangely, which worries Eric and the kids, who fear it may get worse when she hears that others have made alternate plans.