The crews work to contain a dangerous forest fire and save a group of environmentalists protesting a housing development.
When murder victims are found to have used the same ride-share app just before their deaths, the BAU investigate.
When a 200-year-old medicine jar shatters in a teenager's palm, she is admitted to the hospital with symptoms closely linked to smallpox; House must make a dangerous decision that puts his life in jeopardy; Wilson and Sam comfort a young patient.
In order to solve a murder, the team enters the world of unwed mothers during the 1950s and '60s, and the maternity homes where they were hidden.