When Lex is accused of killing a young woman, Clark tries to establish his innocence by seeking Lionel's help.
Sam and Dean tackle a case where people vanish into thin air, leaving only their clothes behind; Dean becomes a victim.
After reading from a spell book from the 1600s, Lana, Lois and Chloe are possessed by vengeful witches who were burnt at the stake; Clark is unable to stop witches from wreaking havoc on the town.
The agents investigate deaths and disappearances near a lake where small-town residents revive stories about a legendary killer sea serpent.
The season two premiere begins three months after Tom Mason agreed to go with the alien invaders. When Tom suddenly returns, he is faced with doubt about his loyalties to the group.