Regi Davis

While undergoing aggressive cancer treatment, Izzie focuses on planning Meredith and Derek's wedding; Callie's father visits; Owen seeks help with his PTSD.

Michael is so smitten with Gob's girlfriend that he decides to let her know that Gob has been cheating on her, and Lucille tries to break up Buster and Lucille Austero.

Prentiss resigns, Hotch requests a transfer and Gideon goes missing, leaving the team three members short as they hunt a serial killer in Milwaukee, who kidnaps women from public places.

All reassess their personal lives after witnessing a chance reunion between two long-lost lovers in the emergency room; Karev treats a troubled teen; Meredith shares her suspicions with Cristina.

While Michael is questioned by the police about Kitty's disappearance, Gob takes George-Michael shoplifting at the department store where Lindsey just got a job.

After learning that his father is in prison for doing business with the old Iraqi government, Michael decides to wash his hands of the whole family and leave town for good.