A meningitis scare overwhelms the resources and staff of the hospital. House singles out a 12-year-old patient whose symptoms are similar to but not quite right for the disease.
A convicted murderer escapes and begins to kill again, and the assailant's original arresting officer, Mac Taylor, comes to help Horatio Caine recapture the felon.
A return to high school brings Melinda into contact with a dead cheerleader and her troubled former squad.
The team investigates when the teenage son of a Secret Service agent disappears. They discover a long-festering secret that sets in motion a deadly chain of events. Recurring guest star Steven Weber appears as Clark Medina.