The team travel to Portland to stop a gang of suspected murderers, that appear to be targeting a new victim each night before they can strike again.
The sister of Booth's detective friend, Ken, goes missing. When the decapitated head is found, Ken joins Brennan and Booth to help solve her murder.
When Sheldon refuses to tell anyone why he's never mentioned his childhood friend Tam, Leonard steps in. Bernadette and Penny invite Raj's fiancée out to dinner to learn more about her.
When a young man in need of immediate emergency surgery goes missing with a bullet lodged in his chest, Ethan asks Magnum and Higgins to find him before it's too late; TC talks to a military recruit who may be enlisting for the wrong reasons.
Don and Charlie investigate the murder of a judge's wife, but it is unclear whether she was the intended target as her husband is hearing a death penalty case involving a gang leader.