When Zod releases a virus into Metropolis that turns humans into zombies, the only way to stop the epidemic could expose Clark's secret identity.
Ingrid struggles with the consequences of a spell. Joanna tries to discover who might be responsible for framing her. Wendy begins teaching Ingrid and Freya how to use their powers. Freya gets a new co-worker at the bar.
While Jamie is under arrest, she manages to manipulate Mitch and Logan into helping her hunt shepherds, members of a secretive group responsible for sterilising humans.
Wes insists to the president that all children with symptoms be quarantined to weaken Drill. Sean confronts a reporter who wants to expose Drill to the world.
The team sets out on a rescue mission for Abe and Dariela's son, Isaac. Mitch and Jamie travel to California and cross paths with a familiar face from their past.