While living in Africa, Jackson Oz finds a link between his late father's theories about a threat to the human race and mysterious animal attacks; similar unusual animal behaviour starts taking place in Los Angeles.
When NASA chooses seven men to be the first astronauts in space, their wives face unexpected sudden fame overnight. Louise is the first to experience change when her husband is chosen.
Louise and Alan enjoy the benefits of the first mission's success while Betty seeks support as Gus' launch nears. Annie, meanwhile, struggles with a speech impediment.
Rene prepares for husband Scott's launch into space with a magazine interview while Deke receives difficult news.
A move to Houston for the familes changes roles for Trudy, Marge and the women as the world faces crisis.