Cristina, back from her honeymoon trip, searches in vain for Burke; Meredith, Cristina, Izzie and Alex spend their first day as residents with their own groups of interns.
Zoe feels a stab of jealousy when she spots Wade with another woman, and Lavon's decision to hire Lemon as his campaign manager may cost him.
The delectable doctor will see us once more. It's a dog's life for George when he is charged with looking after Tansy's disappearing mutt.
After a summer in New York, Zoe goes back to BlueBell for one last thing; Brick offers to write Zoe a good reference if she tracks down George; Lemon helps Wade save face.
Lavon and AnnaBeth invite Zoe and Joel (Josh Cooke) to dinner; Lemon meets Alabama's most eligible bachelor (Ryan McPartlin); George makes a bad decision that could impact his friendship with Lavon.