When Venezuela's president and his immediate successors die in an earthquake, Elizabeth must stop the late president's son from taking over, and she must negotiate the release of some international aid workers that he arrested.
Criss and Liz's relationship is put to the test during on a trip to IKEA; Jack discovers that he and his mother-in-law are attracted to each other; Frank and Tracy try to find a date for Lutz.
An issue with his back hinders Hank's ability to treat patients; Dr Van Dyke fills in; Divya and Jill work to save a thief.
Hank treats an asthmatic boy; Paige's secret is exposed to everyone; Divya's date comes with a surprising outcome.
While Mike (Michael J. Fox) and Annie (Betsy Brandt) are taken surprised by the age of Ian’s (Conor Romero) new girlfriend (guest star Brooke Shields), Harris (Wendell Pierce) and Leigh (Katie Finneran) struggle to be just friends and Eve (Juliette Goglia) experiments with marijuana.