Wayne Lopez

Izzie copes with the loss of Denny and her decision to leave the internship program; Meredith faces decisions about her future after her liaison with Derek.

A series of deaths at the hospital brings out the superstitious side of the doctors and makes Izzie nervous about Denny's surgery; Derek and Addison discuss living arrangements; Richard treats an old friend.

The interns deal with a family involved in a car accident and Derek lets his emotions get the best of him; Burke and Izzie make a suggestion to Denny.

Derek and Meredith get ready for their wedding; college students injured in a car accident are admitted to the ER; Izzie starts experiencing familiar symptoms.

Robin, desperate to find a job before she is deported, agrees to let Barney produce a video resume for her.

A small plane crash in Seattle causes multiple casualties and brings back horrible memories for the doctors, especially Meredith and Arizona. Meanwhile, friction between Owen and Amelia makes for an uncomfortable working situation for Stephanie.