A sexually transmitted disease infects several members of hospital staff. Izzie and Cristina worry about a patient whose wife and daughter are at odds over his care. A bombshell is dropped just as Meredith and Derek grow closer.
Jim and Pam reunite after months apart, as the Scranton and Stamford branches are finally merged.
Michael attempts to be supportive when he finds out one of his new employees, presumably someone from the Stamford branch, has a prison record.
Amy and Sheldon spend Thanksgiving at the aquarium, but just as friends. Wolowitz volunteers at the soup kitchen with Raj, Emily and Bernadette and Penny realises that Leonard knows her better than she thought.
Roz has heard a juicy piece of gossip, that one of the highly-paid stars on KACL has to be fired, and tells Frasier. When Frasier tells the rumour to Father Mike, an interesting chain of events ensues.