Newly orphaned Henrietta is welcomed into a secret agency and trained, along with her sibling Jose, to become a lethal assassin.

Henrietta tries to fit in at the agency. Jose does his best to help her become the most successful assassin the agency has ever seen.

The agency gives Rico a new body, but she must obey their every command. Rico meets Emilio, and his vibrant personality makes her question who she is.

The tension between Hilshire and Triela could endanger their mission to protect Mario Bossi, a retired criminal who's become a government witness.

The agency offers a former military policeman injured on the job a new life and a new job, and he is teamed up with young assassin Claes.

Jose and Henrietta are sent to stop notorious terrorist Enrico Berdini from acquiring an explosive device and attacking Rome.