June has a biopsy and, when a mark appears on the site, she has surgery, leaving her with a growing open wound; her doctor diagnoses her with a flesh eating virus.
After moving houses, and months of strange behaviour, 11-year-old Sammy stops walking and only hops; the doctors are the only hope to discover the cause of his bizarre symptoms.
Jessica is stricken with chills, fever, and migraines; Jake starts military training and finds painful lumps on his body.
A baby continuously gets bruises and spots all over her body; then, a tiny scratch causes excessive bleeding and her parents are very concerned; the doctors do what they can to find out what is wrong.
Karen, a woman who suffers from blindness and albinism, is diagnosed with Crohn's disease, a rare condition that leads to doctors removing her lower intestine.
Lonnie's dreams of playing in the NFL are destroyed when boils develop on his head; plus, Theresa suffers sight loss during her pregnancy; physicians struggle to find a diagnosis.