Former CIA agent Erica Shepherd, one of the most notorious traitors in recent American history, is brought out of a federal Supermax prison by FBI agent Will Keaton to help track down the criminal who is behind a coordinated attack on three cities.

When a former CIA operative is murdered, Keaton enlists Shepherd to help recover valuable intel that could take down Tal once and for all.

Upon discovery that a US ambassador is selling classified intelligence to a Colombian cartel, Shepherd devises a plan to catch him that will push Keaton's moral code to the brink; Keaton brings a new member onto the team.

When intelligence obtained by Shepherd during her stint at the notorious ADMAX prison is linked to a pending attack on US soil, Keaton and the CoIntel team embark on a manhunt to find and stop a deadly international operative.

Once Shepherd convinces Keaton that Anna Cruz is a mole inside the FBI working for Tal, Keaton decides to keep his enemies close; Keaton and the team spy on one of their own, hoping Cruz will lead them to Tal.

After a bomb explodes in Jersey City, the CoIntel team captures a key planner who can lead them to Tal, the mastermind behind the bombing; Shepherd and Keaton end up on a mission to stop another bomb from going off.