Neil deGrasse Tyson talks about the history of the scientific method, and how mathematics and physics were used to predict the location of Neptune before it was even discovered.

Neil deGrasse Tyson talks about the fundamentals of matter. He looks at the discovery of the electron, proton, neutron, quark, and neutrino. He also discusses Einstein's theories of relativity.

Neil deGrasse Tyson discusses the origin of life in the universe. He considers reflections by the astronomer Christiaan Huygens before discussing why life's origin is such a difficult scientific topic.

Neil deGrasse Tyson talks about the mysteries of the periodic table, the fundamental particles that make up matter and transmit forces, and examines string theory and the mystery of black holes.

Neil deGrasse Tyson talks about the move from classical physics to modern physics. He discusses how dark matter accounts for the gravity of the universe even though we know next to nothing about it and examines dark energy.

Neil deGrasse Tyson talks about quantum mechanics and relativity. He considers the possibility of the multiverse, matter/antimatter asymmetry, and whether anything can travel faster than light.