While living in Africa, Jackson Oz finds a link between his late father's theories about a threat to the human race and mysterious animal attacks; similar unusual animal behaviour starts taking place in Los Angeles.

When Jackson's best friend, Abraham, has a dangerous encounter with a lion, Abraham thinks lions might be killing humans for sport; Chloe tries to overcome her trauma and resume working as a government intelligence analyst in Paris.

Jackson wants go to Japan to recover the rest of his father's research on animals; Jamie invites Mitch on a trip to her hometown to present their findings on the zoo lions' abnormal behavior; Chloe is recruited by an intelligence agent.

The team travels to Mississippi to investigate the wolf attack on the prison; the team meets an agent who may have knowledge about the prison fire.

Agent Shaffer, Jamie and Jackson look for a chemist in Alabama who has evidence of Reiden Global's role in the animal problem; Chloe, Mitch and Abraham are faced with a ruthless drug lord in Rio de Janeiro.

Abraham must save Mitch and Chloe when they are abducted by a drug lord; the search for Evan Lee Hartley and the stolen evidence puts Jamie in trouble with the FBI.