Cast en crew
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Tom HanksDr. Henry Goose / Hotel Manager / Isaac Sachs / Dermot Hoggins / Zachry - Halle BerryNative Woman / Jocasta Ayrs / Luisa Rey / Indian Party Guest / Ovid / Meronym
- Jim BroadbentCaptain Molyneux / Vyvyan Ayrs / Timothy Cavendish / Korean Musician / Prescient 2
- Hugo WeavingHaskell Moore, Tadeusz Kesselring
- Jim SturgessAdam Ewing / Poor Hotel Guest / Megan's Dad / Highlander / Hae-Joo Chang / Adam / Zachry Brother In Law
- Bae DoonaSonmi-45
- Ben WhishawCabin Boy / Robert Frobisher / Store Clerk / Georgette / Tribesman
- James D'ArcyYoung Rufus Sixsmith / Old Rufus Sixsmith / Nurse James / Archivist
- Susan SarandonMadame Horrox / Older Ursula / Yusouf Suleiman / Abbess
- Hugh GrantKona Chief
- Keith DavidKupaka / Joe Napier / An-Kor Apis / Prescient
- Xun ZhouTalbot / Hotel Manager / Yoona-939 / Rose
- David GyasiAutua / Lester Rey / Duophysite
- Robert FyfeOld Salty Dog
- Martin WuttkeMr. Boerhaave
- Robin MorrisseyYoung Cavendish
- Brody Nicholas LeeJavier Gomez
- Götz OttoGroundsman Withers
- Lana WachowskiRegisseur
- Lilly WachowskiRegisseur
- Tom TykwerRegisseur
- Grant HillProducent
- Stefan ArndtProducent
- Lana WachowskiProducent
- Tom TykwerProducent
- Lilly WachowskiProducent
- Philip LeeProducent
- Uwe SchottProducent
- Wilson QiuProducent
- Lana WachowskiSchrijver
- Lilly WachowskiSchrijver
- Tom TykwerSchrijver