In California, a group of women struggle with personal problems as their paths intertwine in unexpected ways. Dr. Elaine Keener (Glenn Close), the sole caretaker for her aging mother, turns to tarot card reader Christine (Cameron Diaz) for spiritual aid. Christine grapples with her own angst due to her lover's debilitating illness. Meanwhile, a bank manager (Holly Hunter) deals with an unwanted pregnancy, two sisters pursue romantic interests and a housewife gets back into the dating game.