Conrad takes Trevor under his wing to care for a patient whose good luck seems to have run out; Leela struggles when given the decision to take full responsibility of her indecisive patient's life.
A new group of interns, which include Billie's son, start their first day; Kit and Bell try to convince Conrad to come back to Chastain; Leela and Padma deal with an unexpected visit from their parents.
A case turns personal for Conrad when the donor recipient of Nic's heart is admitted to the emergency room; Bell is faced with a devastating diagnosis that causes him to make a heartbreaking decision.
When Conrad confronts a pharmacy owner about fraudulent prescriptions being filled under his name, the situation takes a dangerous turn; the ER is sent into chaos when a street racing accident results in multiple severe injuries.
Conrad treats one of Gigi's fellow classmates whose stomachache turns into something much more serious; Devon takes several interns to a senior living facility; Leela uncovers some unsettling news.